Andre Levchenko

Andre Levchenko's picture
John C. Malone Professor of Biomedical Engineering
Systems Biology Institute
+1 (203) 737-3088
andre.levchenko@yale.edu
Research Website
Research Areas: 
Biophysics
Research Type: 
Experimentalist
Current Projects: 

Quantitative analysis of signaling pathways regulating biological phenotype: Signaling Pathway Dynamics, Gradient Sensing, Bacteria-Host Interactions, Differentiation of Stem Cells, Control of Cell Shape & Polarity, Hetertypic Cell Interaction, Networks

Research: 
Systems Biology; Signal Transduction and Cell-Cell Communication; Cell Decision Making; Microfluidics and Micro- and Nano-fabrication; Stem Cell Engineering
 
Honors & Awards: 
  • 1999-2001: Computational Molecular Biology Post-Doctoral Fellowship from the Burroughs Wellcome Fund (Caltech Initiative in Computational Molecular Biology)
  • 2003: Invited Participant (among 100 biologists, engineers, chemists and physicists) in the National Academies Inaugural Keck Futures conference on Signals, Decisions, and Meaning, in Biology, Chemistry, Physics, and Engineering
  • 2005: Inaugural Distinguished Guest lecturer, Molecular and Cellular Biology Program, University of Virginia
  • 2009: Featured as an Outstanding Young Scientist in a special issue of Molecular Biosystems
  • 2010: American Asthma Foundation Early Excellence Award
  • 2013: Elected Fellow of the American Institute for Medical and Biological Engineering
Selected Publications: 
  • Levchenko, A., Bruck, J. and Sternberg, P.W. Scaffold proteins can alter multiple parameters of MAP kinase signaling modules. Proceedings of the National Academy of Science USA 97(11):5818-23 (2000)
  • Hoffmann, A.*, Levchenko, A.*, Scott, M.L. and Baltimore, D. The IκB-NF-κB signaling module: temporal control and selective gene activation. Science, 298: 1241-1245 (2002) (selected as a Hot Paper by The Scientist magazine and as an Exceptional paper by Faculty of 1000)
  • Levchenko, A.,* Mehta*, B.M., Niu, X., Kang, G., Villafania, L., Way, D., Sadelain, M. and Larson, S.M. Intercellular transfer of P-glycoprotein mediates acquired multidrug resistance in tumor cells. Proceedings of the National Academy of Science USA 102(6):1933-38 (2005)
  • Barken, D.*, Wang, C.J.*, Kearns, J., Cheong, R., Hoffmann, A. and Levchenko, A. Comment on “Oscillations in NF-kappaB signaling control the dynamics of gene expression”. Science 308(5718):52 (2005)
  • Levchenko, A. Proteomics takes stem cell analyses to another level. Nature Biotechnology 23(7):828-30 (2005)
  • Groisman, A., Lobo, C., Cho, H.J., Campbell, J. K., Dufour, Y.S., Stevens, A.M. and Levchenko, A. A microfluidic chemostat for experiments with bacterial and yeast cells. Nature Methods 2(9): 685-689 (2005)
  • Prill, R., Iglesias, P.A. and Levchenko, A. Dynamic Properties of Small Regulatory Motifs Contribute to Biological Network Organization. PLoS Biology 3(11): e343 (2005)
  • Paliwal, S., Iglesias, P.A., Campbell, J.K., Groisman, A. and Levchenko, A. MAPK-mediated bimodal gene expression and adaptive gradient sensing in yeast. Nature 446(7131):46-51 (2007)
  • Socolovsky, M.*, Murrell, M.*, Liu, Y., Pop, R., Porpiglia, E. and Levchenko, A. Negative autoregulation by Fas mediates robust fetal erythropoiesis. PLoS Biology 5(10): e252 (2007)
  • Cho, H.J.*, Jönsson, H.*, Campbell, J.K., Melke, P., Williams, J.W., Jedynak, B., Stevens, A.M., Groisman, A. and Levchenko, A. Self-organization in high density bacterial colonies: Efficient crowd control. PLoS Biology 5(11): e302 (2007)
  • Kaneda, A.*, Wang, C.J.*, Cheong, R., Timp, W., Iacobuzio-Donahue, C.A., Onyango, P., Andraos, R., Pearson, M.A., Sharov, A.A., Longo, D.L., Ko, M.S.H., Levchenko, A. and Feinberg, A.P. Enhanced sensitivity to IGF-II signaling links loss of imprinting of IGF2 to increased cell proliferation and tumor risk. Proceedings of the National Academy of Science USA 104 (52): 20926–20931 (2007)
  • Rey, S., Lee, K.-A., Wang, C.J., Gupta, K., Chen, S., McMillan, A., Bhise, N., Levchenko, A. and Semenza, G.L. Synergistic Effect of HIF-1α Gene Therapy and HIF-1-activated Bone Marrow-Derived Angiogenic Cells in a Mouse Model of Limb Ischemia. Proceedings of the National Academy of Science USA 106(48): 20399-20404 (2009) (Highlighted by the journal)
  • Kim, D.H.*, Lipke, E.*, Kim, P., Cheong, R., Edmonds, S., Delannoy, M., Suh., K.Y., Tung, L and Levchenko, A. Nanoscale cues regulate the structure and function of macroscopic cardiac tissue constructs. Proceedings of the National Academy of Science USA 107(2): 565–570 (2010)
  • Fosbrink, M., Aye-Han, N.-N., Cheong, R., Levchenko, A. and Zhang, J. Visualization of JNK activity dynamics with a genetically encoded fluorescent biosensor. Proceedings of the National Academy of Science USA 107(12):5459-64 (2010)
  • Fan, D.*, Yin, Z.*, Cheong, R., Zhu, F.Q., Cammarata, R.C., Chien, C.L. and Levchenko, A. Sub-cellular resolution delivery of a cytokine via precisely manipulated nanowires. Nature Nanotechnology 5(7):545-51 (2010) (featured on the cover and highlighted in the News and Views in the journal)
  • Ni, Q.*, Ganesan, A.*, Aye-Han, N.N.*, Gao, X., Levchenko, A., and Zhang, J. Signalling Diversity of PKA achieved via a Ca2+-cAMP-PKA Oscillatory Circuit. Nature Chemical Biology 7(1):34-40 (2011) (highlighted by the journal and Faculty of 1000 as ‘must read’))
  • Hur, E.-M., Yang, I.H., Kim, D.H., Byun, J., Saijilafu, S., Xu, W.-L., Nicovich, P., Cheong, R., Levchenko, A., Thakor, N. and Zhou, F.-Q. Engineering neuronal growth cone to promote axon regeneration over inhibitory molecules. Proceedings of the National Academy of Science USA 108(12):5057-62 (2011)
  • Cheong, R., Rhee, A., Wang, C.J., Nemenman, I. and Levchenko, A. Information transduction capacity of noisy biochemical signaling networks. Science 334(6054):354-8 (2011) (highlighted in the News and Views in the same issue of the journal, in a podcast in Science Signaling and a research highlight in Biopolymers)
  • Wang., J.C., Bergmann, A., Lin, B., Kim., K. and Levchenko, A. Diverse sensitivity thresholds in dynamic signaling responses by social amoebae. Science Signaling 5(213): ra17 (2012) (Cover story, highlighted in a News and View and a highlight article in the same issue of the journal)
  • Garzon-Muvdi, T., ap Rhys, C., Smith, C., Kim, D.H., Kone, L., Farber, H., An, S., Levchenko, A., and Quinones-Hinojosa, A. Regulation of brain tumor dispersal by NKCC1 through a novel role in focal adhesion regulation. PLoS Biology 10(5): e1001320 (2012)
  • Kshitiz, Hubbi, M.E., Ahn, E.H., Downey, J., Afzal, J., Kim, D.H., Rey,S., Chang, C., Kundu, A., Semenza, G.L., Abraham, R.M. and Levchenko, A. Matrix rigidity controls endothelial differentiation and morphogenesis of cardiac precursors. Science Signaling 5(227):ra41 (2012) (Cover image; featured in “The matter of the heart” Science 336 (6088):1483-84 (2012) and the JHU press release)
  • Brennan, M.D., Cheong, R. and Levchenko, A. How Information Theory Handles Cell Signaling and Uncertainty. Science 338(6105): 334-335 (2012)
  • Lin, B., Holmes, W.R., Wang, C.J., Ueno, T., Harwell, A., Edelstein-Keshet, L., Inoue, T. and Levchenko, A. Synthetic spatially graded Rac activation drives cell polarization and movement. Proceedings of the National Academy of Science USA 109(52):E3668-77 (2012)
  • Hubbi, M.E., Kshitiz, Gilkes, D.M., Rey, S., Wong, C.C., Luo, W., Kim, D.H., Dang, C.V., Levchenko, A., and Semenza, G.L. A Non-Transcriptional Role for HIF-1α as a Direct Inhibitor of DNA Replication. Science Signaling 6(262):ra10 (2013)

Editorial Boards:

  • PLoS Biology
  • Science Signaling
  • International Journal of Biological Sciences
  • Expert Opinion in Drug Development